Dr. Harry A. McKellop, Ph.D.

Dr. McKellop received his B.S. degree in 1970 and M.S. in 1973, both in Mechanical Engineering from the University of California, Los Angeles, with emphasis on orthopaedic biomechanics and biomaterials. He was appointed Assistant Professor of Orthopaedics at UCLA in 1979. In 1980 he moved to the University of Southern California, and obtained his Ph.D. in Mechanical Engineering in 1988.

Dr. McKellop is Vice President for Research at Los Angeles Orthopaedic Hospital and Director of the J. Vernon Luck Orthopaedic Research Center. His research involves the biomechanics of the tissue of the skeletal system, including tendons, ligaments, cartilage and bone, as well as orthopaedic implants such as fracture fixation devices and artificial joints. Recent studies have examined the effect of motion (interfragmentary strain) on the healing response of long bone fractures, including the influence of the mechanical properties of the device used to stabilize the fracture. A major part of his research presently focuses on the friction and wear properties (tribology) of materials used in artificial hip joints, including UHMW polyethylene, cobalt-chromium and titanium alloys, and alumina and zirconia ceramics. Specific studies include how modification of the molecular structure of polyethylene affects its wear resistance (NIH funded), and how the proteins present in joint fluids contribute to lubrication of the bearing surfaces.

In addition to the Biomechanics and Tribology laboratories, the J. Vernon Luck Center incorporates laboratories specializing in Biochemistry, Bone Physiology, Endocrinology and Biocompatibility, and collaborates with the surgical faculty of the UCLA Department of Orthopaedics as well as the JRI.

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Dr. Edward Ebramzadeh, Ph.D.

Dr. Ebramzadeh received his B.S. in 1980, and his M.S. in 1981, both in Mechanical Engineering from the University of Southern California. He started working in Biomechanics Research in 1982, and was appointed Instructor of Research Orthopaedics at the USC Department of Orthopaedics in 1986. In 1995, he obtained his Ph.D. from the Department of Biomaterials and Handicap Research at Göteborg University.


He has since been the Director of the Implant Performance Laboratory, a subdivision of the J. Vernon Luck, Sr., M.D. Orthopaedic Research Center at Orthopaedic Hospital.

Research at the Implant Performance Laboratory primarily involves the design, testing and evaluation of implants, and methods for the fixation of fractures and soft tissues. Current projects include: the effects of femoral stem surface roughness and cement thickness on its initial stability and on load transfer to the proximal femur; comparison of four methods to measure acetabular cup wear from radiographs; effects of malunion of the distal radius on radio-ulnar joint pressures; comparison of three methods to fix rotator cuff tears; and changes in bone density in patients receiving surface replacements. Dr. Ebramzadeh was also part of the team that developed the Uniflex intramedullary nail system in collaboration with Biomet.

In addition to bench-top models, Dr. Ebramzadeh established the Research Computing facility at Orthopaedic Hospital which has been instrumental in a variety of clinical follow-up studies. As an example, this facility has maintained and analyzed clinical and research data on 1800 total hip replacement patients followed for up to 27 years. Statistical methods, including survivorship analysis and multivariate analysis techniques, have been adopted to assess the effects of hip component design variables, patient characteristics and surgical variables on the long term outcome of these hip replacements. Survivorship analysis has also been used to assess the outcome with many orthopaedic treatments, such as patients with osteogenesis imperfecta treated with Baily-Dubow extensible intramedullary nails, and outcome of forearm fractures in children treated with and without internal fixation.

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Dr. Pat Campbell, Ph.D.

Dr. Campbell  received her Bachelor of Science degree in Anatomy and Human Biology at the University of Western Australia. She came to the United States in 1983 when she was recruited to help establish an implant retrieval laboratory at the Biomechanics Department of Orthopaedic Hospital. She then spent several years at the Harrington Arthritis Research Center in Phoenix, Arizona before returning to Los Angeles in 1988 to direct the Implant Retrieval Lab at the Division of Orthopaedic Surgery at UCLA under the direction of Dr. Harlan Amstutz.

Dr. Campbell’s current interest in the problem of component wear was engendered during her time at UCLA and has carried over to her current position at the JRI where she is Director of the Implant Retrieval Lab. Her interest in this field led to the completion of a Ph.D. in Medical Sciences in February, 1995. In conjunction with the alliance between Orthopaedic Hospital and UCLA, Dr. Campbell was named an Associate Professor in the Department of Orthopaedic Surgery. She continues to be involved with retrieved component analysis, wear particle isolation and characterization, and the histopathological evaluation of periprosthetic tissues.

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Dr. Frederick Dorey, Ph.D

Dr. Dorey received his Ph.D. in mathematics from the University of Massachusetts in 1969. After receiving tenure in the Mathematics Department at George Mason University he came to Los Angeles to pursue his evolving interest in statistics. This began a twenty-three year career of statistical teaching and consulting at the UCLA School of Medicine. Today Dr. Dorey continues an association with Dr. Harlan Amstutz (that began at UCLA in 1983) as a statistical consultant for the Joint Replacement Institute.

He is a member of the Hip Society and has recently achieved the rank of Professor at UCLA. Dr. Dorey is best known for his writings and presentations involving the use of proper statistical analysis in the evaluation of orthopaedic data with an emphasis on the use of survivorship analysis in the long term evaluation of total hip arthroplasty. He is a co-author on over 130 published articles in the medical literature and is a co-editor on a recently published book on the subject of hip arthroplasty outcomes. Dr. Dorey is married and has a son who is entering his teenage years.

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